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Concise Pathology, 3e | Part A. General Pathology > Section III. Agents Causing Tissue Injury > | Chapter 9. Abnormalities of Blood Supply Sections: Abnormalities of Blood Supply: Introduction, Causes of Tissue Ischemia, Effects of Tissue Ischemia, Causes of Vascular Occlusion. Excerpt:"The maintenance of adequate blood circulation is a highly complex process that depends on proper function of the heart, the integrity of the vasculature, and the maintenance of a delicate balance between the coagulation and fibrinolytic systems. Failure of blood supply to a tissue (ischemia) may be localized, due to arterial obstruction or deficient venous drainage, leading to infarction (ischemic necrosis of tissue); or generalized, due to severe decrease in cardiac output, leading to a generalized decrease in tissue perfusion (shock)...."
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