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Clinician's Pocket Reference: The Scut Monkey, 11e
Metronidazole (Flagyl, MetroGel)
Topics Discussed: metronidazole.
Excerpt:
"Uses: *Bone/joint,
endocarditis, intraabdominal, meningitis & skin Infxns; amebiasis;
trichomoniasis; bacterial vaginosis* Action: Interferes
w/DNA synthesis Spectrum: Excellent
anaerobic C. difficile, also H. pylori in combo therapy Dose: Adults. Anaerobic Infxns: 500 mg IV q6–8h. Amebic dysentery: 750 mg/d
PO for 5–10 d. Trichomoniasis: 250
mg PO tid for 7 d or 2 g PO x 1. C. difficile Infxn: 500 mg PO or IV
q8h for 7–10 d (PO preferred; IV only if pt NPO). Vaginosis: 1 applicatorful intravag
bid or 500 mg PO bid for 7 d. Acne rosacea/skin: Apply
bid. Peds. Anaerobic Infxns: 15 mg/kg/24
h PO or IV ÷ q6h. Amebic dysentery: 35–50
mg/kg/24 h PO in 3 ÷ doses for 5–10 d;  in
hepatic impair Caution: [B,
M] Avoid EtOH Contra: First
tri of PRG Supplied: Tabs 250, 500
mg; XR tabs 750 mg; caps 375 mg; topical lotion & gel 0.75%;
intravag gel 0.75% (5 g/applicator 37.5 mg in
70-g tube), cream 1% SE: Disulfiram-like
Rxn; dizziness, HA, GI upset, anorexia, urine discoloration Notes:..."
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