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Clinician's Pocket Reference: The Scut Monkey, 11e
Trimethoprim (TMP)–Sulfamethoxazole (SMX), Cotrimoxazole (Bactrim, Septra)
Excerpt:
"Uses: *UTI Rx & prophylaxis,
otitis media, sinusitis, bronchitis* Action: SMX  synthesis
of dihydrofolic acid, TMP dihydrofolate
reductase to impair protein synthesis. Spectrum: Includes Shigella, P. jiroveci (formerly carinii) & Nocardia Infxns, Mycoplasma, Enterobacter sp, Staph, Strep & more Dose: Adults. 1
DS tab PO bid or 5–20 mg/kg/24 h (based
on TMP) IV in 3–4 ÷ doses. P. jiroveci: 15–20
mg/kg/d IV or PO (TMP) in 4 ÷ doses. Nocardia: 10–15 mg/kg/d
IV or PO (TMP) in 4 ÷ doses. UTI prophylaxis: 1
PO qd. Peds. 8–10 mg/kg/24
h (TMP) PO ÷ into 2 doses or 3–4 doses IV; do
not use in newborns; in renal failure;
maintain hydration Caution: [B
(D if near term), +] Contra: Sulfonamide
sensitivity, porphyria, megaloblastic anemia w/folate deficiency,
significant hepatic impair Supplied: Regular
tabs 80 mg TMP/400 mg SMX; DS tabs 160 mg TMP/800
mg SMX; PO susp 40 mg TMP/200 mg SMX/5 mL; inj
80 mg TMP/ 400 mg SMX/5 mL SE: Allergic
skin..."
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