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MD Anderson Manual of Medical Oncology
Histology
Sections: Adenocarcinoma, Squamous Cell Carcinoma, Large Cell Carcinoma, Other Types.
Topics Discussed: adenocarcinoma of lung; carcinoma, large cell; lung cancer; non-small-cell lung carcinoma; squamous cell carcinoma of lung.
Excerpt:
"The majority of lung tumors arise from epithelial cells and are
called bronchogenic carcinomas. Neuroendocrine tumors also arise
in the lung and can appear as SCLCs, carcinoids, or large cell neuroendocrine
carcinomas. Bronchogenic carcinomas include NSCLCs, a category comprising three
major types: adenocarcinoma, squamous cell carcinoma (SCC), and
large cell carcinoma. The proportion of adenocarcinoma NSCLCs has
been increasing over the past two decades. Reasons for this increase
have not been established but might include changes in smoking habits
and the use of low-tar or filtered cigarettes.Adenocarcinoma is the most common subtype of NSCLC in the United
States and constitutes 54% of all NSCLC cases (43). Although
adenocarcinoma is associated with smoking, it is especially predominant
among women and nonsmokers. These tumors are classically peripheral
and arise from surface epithelium or bronchial mucosal glands and
as peripheral scar carcinomas. On histologic examination, adenocarcinoma
demonstrates gland formation, papillary structures, or mucin production
(Fig. 12-1)...."
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