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Harrison's Principles of Internal Medicine, 17e
| Part Sixteen: Neurologic Disorders > Section 3: Nerve and Muscle Disorders > |
Chapter 381. Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
Sections: Myasthenia Gravis and Other Diseases of the Neuromuscular Junction: Introduction, Pathophysiology, Clinical Features, Diagnosis and Evaluation, Myasthenia Gravis: Treatment, Patient Assessment, Further Readings, Bibliography.
Topics Discussed: myasthenia gravis; neuromuscular junction diseases.
Excerpt:
"Myasthenia gravis (MG) is a neuromuscular disorder characterized
by weakness and fatigability of skeletal muscles. The underlying
defect is a decrease in the number of available acetylcholine receptors
(AChRs) at neuromuscular junctions due to an antibody-mediated autoimmune
attack. Treatment now available for MG is highly effective, although
a specific cure has remained elusive...."
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