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Fitzpatrick's Dermatology in General Medicine, 7e | Part 8. The Skin in Systemic Disease > Section 24. Skin in Nutritional, Metabolic, and Heritable Disease > | Dystrophic Calcification Sections: Dystrophic
Calcification, Connective Tissue
Diseases, Panniculitis, Inherited Disorders, Cutaneous Neoplasms, Infections, Other. Topics Discussed: calcium deposit substance; connective tissue disease; crest syndrome; ehlers-danlos syndrome; ossification, physiologic; panniculitis; porphyria cutanea tarda; pseudoxanthoma elasticum; scleroderma; skin diseases, infectious; skin neoplasms.
Excerpt:
"Dystrophic calcification frequently occurs in connective tissue
diseases.16 Scleroderma and CREST syndrome (calcinosis
cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia)
are notable examples that are frequently associated with calcinosis
cutis (Fig. 138-1; see Chap. 158). In these disorders, nodules and plaques of calcium deposits
may occur in the skin, subcutaneous tissue, muscle, or tendons.
The calcium deposits most commonly occur on the upper extremities, especially
on the fingers and wrists, but may occur in any area subject to
trauma or motion. As the calcifications enlarge, they may ulcerate
and exude a chalky material...."
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