|
Fitzpatrick's Dermatology in General Medicine, 7e
| Part 8. The Skin in Systemic Disease > Section 25. Skin Manifestations of Bone Marrow or Blood Chemistry Disorders > |
Chapter 150. Biology of Mast Cells and the Mastocytosis Syndromes
Sections: Biology of Mast Cells, Mastocytosis, Mastocytosis Syndromes, References.
Topics Discussed: mast cell.
Excerpt:
"Mast cells are the primary effector cells in immunoglobulin E
(IgE) mediated inflammatory reactions. They are implicated in both
acquired and innate immune responses, wound healing, fibrosis, angiogenesis,
and autoimmune diseases.Mast cells are widely distributed, long-lived cells found predominately
in connective and mucosal tissues and often in proximity to blood
vessels, nerves, and lymphatic tissues.1 Mast cells
are abundant in the skin, respiratory tract, gastrointestinal tract,
and genitourinary tract. The cytoplasmic granule content, cell size,
and susceptibility to pharmacologic agents vary with specific location.
All human mast cells contain tryptase, histamine, and proteoglycans, including
heparin and chondroitin sulfate E. Mast cells are classically identified
in tissue by toluidine blue or Giemsa dye that stains the cytoplasmic
granules, and more recently, by immunohistochemistry using an antibody
that recognizes mast cell tryptase. Human mast cells are classically divided
into two types. Mast cells that contain tryptase and chymase are
referred to as TC mast cells (MCTC).
Such cells tend to be located in submucosal tissues. Increased numbers
of these cells are found..."
The content above is only an excerpt.
For full access, log into an existing user account below, purchase an annual subscription, or purchase a short-term subscription to the complete website.
|
|
|
|
|