Adams and Victor's Principles of Neurology, 9e
Chapter 31. Intracranial Neoplasms and Paraneoplastic Disorders
Sections: Intracranial Neoplasms and Paraneoplastic Disorders: Introduction, Clinical and Pathologic Characteristics of Brain Tumors, Remote Effects of Neoplasia on the Nervous System (Paraneoplastic Disorders), References.
Topics Discussed: brain tumor; central nervous system tumor; paraneoplastic syndromes, nervous system.
Excerpt:"Tumors of the central nervous system (CNS) constitute a bleak
but vitally important chapter of neurologic medicine. Their importance
derives from their great variety; the numerous neurologic symptoms
caused by their size, location, and invasive qualities; the destruction
and displacement of tissues in which they are situated; the elevation
of intracranial pressure they cause; and, most of all, their lethality.
Slowly, this dismal state of affairs is changing as a result of
advances in anesthesiology, stereotactic and microneurosurgical
techniques, focused radiation therapy and the use of new chemotherapeutic
agents.Currently, in each year there are an estimated 600,000 deaths
from cancer in the United States. Of these, the number of patients
who died of primary tumors of the brain seems comparatively small (approximately
20,000, half of them malignant gliomas), but in roughly another
130,000 patients the brain is affected at the time of death by metastases.
Thus, in approximately 25 percent of all the patients with cancer,
the brain or its coverings are involved by neoplasm at some time
in the course of the illness. Among causes of death from intracranial
disease in adults, tumor is exceeded in frequency only by stroke,
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