Williams Hematology, 8e
|Part XII. Hemostasis and Thrombosis >|
Chapter 115. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
Sections: Summary, Molecular Biology, Biochemistry, and Life Span of the Coagulation Factors, Soluble Cofactors (Protein S, Factor V, Factor VIII, and von Willebrand Factor), Factor XI and the Contact Factors, Cell-Associated Cofactors, Inhibitors, References.
Topics Discussed: blood coagulation factor; hemostatic function.
Excerpt:"Blood coagulation is a very delicately balanced system.
When it functions as it should, the blood is maintained in a fluid
state in the vasculature, yet rapidly clots to seal an injury. When
hemostatic functions fail, hemorrhage or thromboembolic phenomena result.
This chapter addresses molecular and biochemical features of the
proteins of the coagulation system, and how they interact with cells
and with one another to provide hemostasis in the living organism.
We have grouped the coagulation factors as (1) the vitamin-K-dependent
zymogens (prothrombin, and factors VII, IX, X, and protein C); (2)
the soluble cofactors (protein S, factor V, factor VIII, and von
Willebrand factor); (3) factor XI and the other "contact" factors;
(4) cell-associated cofactors (tissue factor and thrombomodulin);
(5) fibrinogen; (6) factor XIII and TAFI; and (7) the plasma coagulation
protease inhibitors. Table 1151 shows
the major features of the coagulation factors addressed in this
chapter. A model of the coagulation pathway is presented that is
based on current understanding of cellcell and cellprotein
interactions that regulate hemostasis. This scheme emphasizes the
importance of cellular localization and plasma protease inhibitors
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