Williams Hematology, 8e
|Part XII. Hemostasis and Thrombosis >|
Chapter 119. Thrombocytopenia
Sections: Summary, Platelet Kinetics, Spurious Thrombocytopenia (Pseudothrombocytopenia), Thrombocytopenia Resulting from Impaired Platelet Production, Thrombocytopenia Resulting from Platelet Trapping, Acquired Thrombocytopenia Resulting from Impaired Platelet Production, Thrombocytopenia Resulting from Accelerated Platelet Destruction, Thrombocytopenia in Patients with Antiphospholipid Syndrome, Thrombocytopenia in Patients with Systemic Lupus Erythematosus and Other Autoimmune Conditions, Thrombocytopenia during Pregnancy, Abnormal Platelet Distribution or Pooling, An Approach to Thrombocytopenia in Children, References.
Topics Discussed: thrombocytopenia.
Excerpt:"Thrombocytopenia is one of the most frequent causes
for hematologic consultation in the practice of medicine, and potentially
one of the most life-threatening. Although the normal platelet count
in humans (150400 x 109/L)
far exceeds the minimal level required to avoid pathologic hemorrhage
(<50 x 109/L), a
number of medical conditions cause either increased destruction
or reduced production of platelets, increasing the risk of pathologic
bleeding. This chapter discusses an approach to the diagnosis of thrombocytopenia,
grouping various causes by mechanism of action, and describing our
current understanding of pathogenesis, treatment, and prognostication.
In the vast majority of patients, a cause for thrombocytopenia can
be identified, and effective therapy instituted.Abbreviations and acronyms that
appear in this chapter include: ADAMTS, a disintegrin and metalloproteinase
with thrombospondin repeats; ALL, acute lymphocytic leukemia; APLA,
antiphospholipid antibody; APS, antiphospholipid antibody syndrome; CAMT,
congenital amegakaryocytic thrombocytopenia; CTP, cyclic thrombocytopenia;
DIC, disseminated intravascular coagulation; EDTA, ethylenediaminetetraacetic
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