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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section II. Neuropharmacology > |
Chapter 14. Neurotransmission and the Central Nervous System
Sections: Neurotransmission and the Central Nervous System: Introduction, Organizational Principles of the CNS, Microanatomy of the Brain, Response to Damage: Repair and Plasticity in the CNS, Integrative Chemical Communication in the CNS, Neurotransmitter Receptor-Effector Coupling in the CNS, Cell Signaling and Synaptic Transmission, Central Neurotransmitters, Other Regulatory Substances, Actions of Drugs in the CNS, Specificity and Nonspecificity of CNS Drug Actions, General (Nonspecific) CNS Depressants, General (Nonspecific) CNS Stimulants, Drugs that Selectively Modify CNS Function, General Characteristics of CNS Drugs, Bibliography.
Topics Discussed: neurotransmission.
Excerpt:"Drugs that act in the central nervous system (CNS) are invaluable therapeutically. They can, e.g., relieve pain, reduce fever, suppress disordered movements, induce sleep or arousal, reduce appetite, and allay the tendency to vomit. Selectively acting drugs can be used to treat anxiety, depression, mania, or schizophrenia and do so without altering consciousness (Chapters 15 and 16). Socially acceptable stimulants and anti-anxiety agents contribute to emotional stability, relief of anxiety, and pleasure. However, the excessive use of such drugs can affect lives adversely when uncontrolled, self-administration leads to physical dependence or to toxic side effects (Chapter 24). The nonmedical self-administration of CNS-active drugs—recreational pharmacology—is widespread...."
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