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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section III. Modulation of Cardiovascular Function > |
Chapter 30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs
Sections: Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs: Introduction, Overview of Hemostasis: Platelet Function, Blood Coagulation, and Fibrinolysis, Parenteral Anticoagulants, Oral Anticoagulants, New Oral Anticoagulants, Fibrinolytic Drugs, Antiplatelet Drugs, The Role of Vitamin K, Clinical Summary, BIBLIOGRAPHY.
Topics Discussed: blood coagulation; chemistry of anticoagulants; coagulation disorders; hemostatic function; pharmacotherapy of hematologic disorders; thromboembolism; venous thromboembolism.
Excerpt:"The physiological systems that control the fluidity of blood are both complex and elegant. Blood must remain fluid within the vasculature and yet clot quickly when exposed to subendothelial surfaces at sites of vascular injury. When intravascular thrombi form, rapid activation of the fibrinolytic system restores fluidity. Under normal circumstances, a delicate balance between coagulation and fibrinolysis prevents both thrombosis and hemorrhages. Alteration of this balance in favor of coagulation results in thrombosis...."
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