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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section IV. Inflammation, Immunomodulation, and Hematopoiesis > |
Chapter 37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins
Sections: Hematopoietic Agents: Growth Factors, Minerals, and Vitamins: Introduction, Hematopoietic Growth Factors, Erythropoiesis Stimulating Agents, Myeloid Growth Factors, Drugs Effective in Iron Deficiency and Other Hypochromic Anemias, Iron and Iron Salts, B12, Folic Acid, and the Treatment of Megaloblastic Anemias, Clinical Summary, Bibliography.
Topics Discussed: hematinics; hematopoiesis.
Excerpt:"The finite life span of most mature blood cells requires their continuous replacement, a process termed hematopoiesis. New cell production must respond to basal needs and states of increased demand. Red blood cell production can increase >20-fold in response to anemia or hypoxemia, white blood cell production increases dramatically in response to a systemic infection, and platelet production can increase 10- to 20-fold when platelet consumption results in thrombocytopenia...."
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