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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section VII. Chemotherapy of Microbial Diseases > |
Chapter 57. Antifungal Agents
Sections: Antifungal Agents: Introduction, Systemic Antifungal Agents: Systemic Drugs for Deeply Invasive Fungal Infections, Bibliography.
Topics Discussed: antibiotics, antifungal; pharmacotherapy of infectious diseases; therapy of microbial diseases; bacterial, viral, fungal, and protozoal infections.
Excerpt:"There are 200,000 known species of fungi, and estimates of the total size of Kingdom Fungi range to well over a million. Residents of the kingdom are quite diverse and include yeasts, molds, mushrooms, smuts, the pathogens Aspergillus fumigatus and Candida albicans, and the source of penicillin, Penicillium chrysogenum. Fortunately, only ~400 fungi cause disease in animals, and even fewer cause significant human disease. However, fungal infections are becoming more common: Patients with AIDS and patients whose immune systems are compromised by drug therapy are especially susceptible to mycotic infections. Fungi are eukaryotes with unique cell walls containing glucans and chitin, and their eradication requires different strategies than those for treatment of bacterial infections. Available agents have effects on the synthesis of membrane and cell-wall components, on membrane permeability, on the synthesis of nucleic acids, and on microtubule/mitotic spindle function (Figure 57–1)...."
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