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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section VII. Chemotherapy of Microbial Diseases > |
Chapter 58. Antiviral Agents (Nonretroviral)
Sections: Antiviral Agents (Nonretroviral): Introduction, Anti-Herpesvirus Agents, Anti-Influenza Agents, Anti-Hepatitis Virus Agents, Other Agents, Bibliography.
Topics Discussed: antiviral agents; chemistry of antiviral agents; pharmacotherapy of infectious diseases; therapy of microbial diseases; bacterial, viral, fungal, and protozoal infections.
Excerpt:"Most antivirals currently available in the U.S. have been developed and approved in the last two decades. This flurry of activity was driven by successes in rational drug design and approval that began with the anti-herpesvirus nucleoside analog acyclovir, whose discovery and development resulted in the awarding of a Nobel Prize to Gertrude Elion and George Hitchings in 1988. Because viruses are obligatory intracellular microorganisms and rely on host biosynthetic machinery to reproduce, there were doubts about the possibility of developing antiviral drugs with selective toxicity, but those doubts have long been erased. Viruses are now obvious targets for effective antimicrobial chemotherapy, and it is certain that the number of available agents in this category will continue to increase...."
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