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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section IX. Special Systems Pharmacology > |
Chapter 67. Environmental Toxicology: Carcinogens and Heavy Metals
Sections: Environmental Toxicology: Carcinogens and Heavy Metals: Introduction, Environmental Risk Assessment and Risk Management, Carcinogens and Chemoprevention, Metals, Treatment of Metal Exposure, Bibliography.
Topics Discussed: heavy metal antagonist; metals, heavy; toxic effect of heavy metal.
Excerpt:"Humans are exposed to chemicals from their environment daily. Fortunately, mammals have evolved mechanisms to protect themselves from toxic effects of many exogenous chemicals, including the xenobiotic transport and metabolic mechanisms described in Chapters 4, 5, 6, and 7. While the human body is relatively well adapted to deal with xenobiotics, there are situations in which such environmental agents may cause significant toxicity. The industrial revolution and the development of chemical industries have increased human exposures to chemicals that were previously infrequent or absent. Occupational exposures to xenobiotics are of particular concern because workers often will be exposed to specific chemicals at concentrations that are orders of magnitude higher than those to which the general population is exposed. Increasing concern about environmental toxicants has stimulated interest and research in environmental toxicology, the study of how chemicals in our environment adversely affect human health, and in occupational toxicology, the study of how chemicals in the workplace affect human health. Myriad authoritative textbooks are available in these areas. This chapter does not attempt a thorough coverage; rather, it sets forth a few basic principles, briefly discusses carcinogens..."
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