AccessMedicine | 1. Post-Transplant Lymphoproliferative Disorder, Polymorphous Type

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Lichtman's Atlas of Hematology

Part VII. Lymphomas and Lymphoid Leukemias >

F. Post-Transplant Lymphoproliferative Disorder

Sections: 1. Post-Transplant Lymphoproliferative Disorder, Polymorphous Type, 2. Post-Transplant Lymphoproliferative Disorder, High Grade.

Excerpt:

Post-transplant lymphoproliferative disorder, polymorphous type. Lymph node sections. (A) Replacement by a mixture of small lymphocytes, larger (activated) lymphocytes, and plasma cells. (B) In situ hybridization indicates expression of Epstein-Barr virus–associated early RNA (EBER). Black nuclear staining represents positive reaction in a significant subset of cells. Flow cytometry studies on the same sample showed a mixed population of B cells and plasma cells. In situ hybridization for kappa and lambda light chain expression confirmed that plasma cells were polyclonal (not shown). This lesion represents a lymph node from a patient..."

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