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Lichtman's Atlas of Hematology
Part X. Cytochemistry and Immunostains >
E. Specialized Patterns of Staining
Sections:
1. BCL-2 Immunostain in Follicular Lymphoma, 2. ALK-1 Immunostain in Anaplastic Large Cell Lymphoma.
Excerpt:
BCL-2 immunostain in follicular lymphoma. These images illustrate the typical staining of (
A
) neoplastic follicles in follicular lymphoma as compared to (
B
) benign, reactive germinal centers. Note that in follicular lymphoma neoplastic centrocytes equivalent to neoplastic germinal center cells overexpress the anti-apoptotic protein BCL-2 (arrows), whereas in reactive germinal center, no appreciable staining is noted (arrow), but mantle zone cells surrounding the germinal center (asterisk) are positive. In follicular lymphoma, the overexpression of BCL-2 can be attributed in about 80% to 85% of cases to a translocation involving..."
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