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Adams and Victor's Principles of Neurology, 9e Chapter 41. Diseases of the Nervous System Caused by Nutritional Deficiency Sections: Diseases of the Nervous System Caused by Nutritional Deficiency: Introduction, Wernicke-Korsakoff Syndrome (Thiamine [B1] Deficiency), Nutritional Polyneuropathy (Neuropathic Beriberi), Pellagra (Niacin [Nicotinic Acid, B3] Deficiency), The Neurologic Manifestations of Vitamin B12 Deficiency (Subacute Combined Degeneration), Disorders Caused by Deficiencies of Fat-Soluble Vitamins, Nutritional Syndromes of Uncertain Etiology, Protein-Calorie Malnutrition and Mental Retardation, Inherited Vitamin-Responsive Neurologic Diseases, References. Topics Discussed: neuropathy, nutritional.
Excerpt:
"Among nutritional disorders, those of the nervous system occupy
a position of special interest and importance. The early studies
of beriberi at the turn of the twentieth century were largely responsible
for the discovery of thiamine, and consequently for the modern concept
of deficiency disease. A series of notable achievements in the science
of nutrition followed the discovery of vitamins. Despite such progress,
a number of diseases caused by nutritional deficiency, and particularly
those of the nervous system, continue to represent a worldwide health
problem of serious proportions. In Far Eastern communities, where
the diet consists mainly of highly milled rice, there is still a
significant incidence of beriberi. In other underdeveloped countries,
deficiency diseases are endemic, the result of chronic dietary deprivation.
And the ultimate effects on the nervous system of intermittent mass
starvation, involving large portions of the African continent, is alarming
to contemplate.The term deficiency is used throughout this
chapter in its strictest sense to designate disorders that result
from the lack of an essential nutrient or nutrients in the
diet or from a conditioning factor that increases..."
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