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CURRENT Diagnosis & Treatment: Cardiology, 3e
Chapter 33. Connective Tissue Diseases & the Heart
Sections: Introduction, Systemic Lupus Erythematosus, Valvular Heart Disease, Pericarditis, Myocarditis or Cardiomyopathy, Thrombotic Diseases, Coronary Artery Disease, Cardiac Arrhythmias & Conduction Disturbances, Rheumatoid Arthritis, Rheumatoid Pericarditis, Rheumatoid Valvular Heart Disease, Rheumatoid Myocarditis, Rheumatoid Coronary Artery Disease, Conduction Disturbances, Rheumatoid Pulmonary Hypertension, Scleroderma, Coronary Artery Disease, Myocarditis, Conduction Disturbances & Arrhythmias, Pericarditis, Valvular Heart Disease, Secondary Scleroderma Heart Disease, Ankylosing Spondylitis, Aortitis & Aortic Regurgitation, Conduction Disturbances, Mitral Valve Disease, Myocardial Disease, Pericardial Disease, & Bacterial Endocarditis, Polymyositis/Dermatomyositis, Myocarditis, Arrhythmias & Conduction Disturbances, Coronary Arteritis, Valvular Heart Disease, Pericarditis, Pulmonary Hypertension, Cor Pulmonale, & Hyperkinetic Heart Syndrome, Mixed Connective Tissue Disease.
Topics Discussed: connective tissue disease.
Excerpt:"The connective tissue diseases are immune-mediated inflammatory diseases, primarily of the musculoskeletal system; however, they frequently also involve the cardiovascular system. The most important of these diseases are systemic lupus
erythematosus, rheumatoid arthritis, scleroderma, ankylosing spondylitis,
polymyositis/dermatomyositis, and mixed connective tissue
disease. They affect the valve leaflets, coronary arteries, pericardium,
myocardium, conduction system, and great vessels with different
rates of prevalence and degrees of severity. Although heart involvement
in patients with connective tissue diseases contributes significantly
to their morbidity and mortality rates, there is a large discrepancy
between clinically recognized heart disease and postmortem series.
Furthermore, the pathogenesis, natural history, and effects of therapy
are incompletely understood. Increased awareness and better understanding
of the cardiovascular disease associated with connective tissue diseases may lead to earlier recognition, treatment and, perhaps, increased longevity...."
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