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Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e
Chapter 185. Nonsteroidal Anti-Inflammatory Drugs
Sections: Epidemiology, Pharmacology, Pharmacokinetics, Significant Drug–Drug Interactions, Clinical Features, Toxicity with Acute Overdose, Treatment, Disposition and Follow-Up, Acknowledgment, References.
Topics Discussed: anti-inflammatory agents, non-steroidal; non-steroidal anti-inflammatory overdose; non-steroidal anti-inflammatory poisoning.
Excerpt:"NSAIDs are among the most widely used and prescribed drugs in
the U.S. This class contains approximately 20 drugs that share inhibition
of the cyclooxygenase enzyme as a mechanism of action. Although
this class also contains acetaminophen and salicylates, these two
drugs possess unique toxicity and are considered in separate chapters
(see Chapter 183, Aspirin and Salicylates,
and Chapter 184, Acetaminophen). NSAIDs are
effective antipyretics, analgesics, and anti-inflammatory agents.
Because of their large therapeutic window, NSAIDs are relatively safe
agents with respect to acute ingestion and overdose, rarely producing
serious complications.1–3 Several agents
are now available without prescription (over the counter), and the
world sales for NSAIDs is reported to be $6 billion per
year in U.S. dollars.4..."
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