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Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e
Chapter 176. Barbiturates
Sections: Barbiturates: Introduction, Pharmacology, Clinical Features, Treatment, Disposition and Follow-Up, Special Considerations, Acknowledgment, References.
Topics Discussed: barbiturates.
Excerpt:"Toxicity from barbiturates has historically been associated with
the highest risk of morbidity and mortality among all sedative-hypnotics.1,2 The therapeutic
use of barbiturates has declined due to the introduction of safer,
less toxic sedative-hypnotics, such as benzodiazepines, and second-generation
anticonvulsants. However, barbiturate overdose and toxicity is still
encountered in the ED. During 2008, the American Association of
Poison Control Centers noted there were 2719 exposures to barbiturates
reported to their centers; 1196 were polydrug exposures that included
a barbiturate, 1523 were single drug exposures to a barbiturate, and
four deaths were identified.3..."
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