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Hurst's The Heart, 13e
| Part 10. Cardiopulmonary Disease > |
Chapter 73. Chronic Cor Pulmonale
Sections: Definition, Incidence, Etiologies, Pathophysiology of Increased Pulmonary Vascular Resistance, Response of the Right Cardiac Ventricle to Increased Pulmonary Vascular Resistance, Clinical Manifestations, Physical Examination, Diagnostic Evaluation, Treatment, Prognosis, References.
Topics Discussed: cor pulmonale.
Excerpt:"Perhaps the most widely accepted general definition of the term cor pulmonale remains the one articulated in 1963 by an expert committee appointed by the director general of the World Health Organization (WHO): Chronic cor pulmonale is "hypertrophy of the right ventricle resulting from diseases affecting the function and/or structure of the lung, except when these pulmonary alterations are the result of diseases that primarily affect the left side of the heart or congenital heart disease."1 In the updated clinical classification of pulmonary hypertension, cor pulmonale can occur due to conditions included in the third (pulmonary hypertension due to lung diseases and/or hypoxia) and fourth categories (pulmonary hypertension due to chronic thrombotic and/or embolic disease).2 Of note, acute dilatation of the right ventricle of the heart, that is, acute cor pulmonale, is a disorder in which the right ventricle is dilated and the muscular wall is stretched thin. This is most often the result of massive pulmonary embolism. The chronic form of the disorder, the principal subject of this chapter, is characterized by right ventricular (RV) hypertrophy with eventual dilatation and right-sided heart failure...."
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