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Harrison's Principles of Internal Medicine, 18e | Part 2. Cardinal Manifestations and Presentation of Diseases > Section 9. Alterations in the SkinĀ > | Chapter 55. Cutaneous Drug Reactions Sections: Cutaneous Drug Reactions: Introduction, Use of Prescription Drugs in the United States, Incidence of Cutaneous Reactions, Pathogenesis of Drug Reactions, Clinical Presentation of Cutaneous Drug Reactions, Drugs of Special Interest, Management of a Patient with a Drug Eruption, Further Readings. Topics Discussed: allergic and pseudoallergic drug reactions; drug allergy; drug eruptions; drugs affecting the integumentary system (skin); toxic responses of the skin. Excerpt:"Cutaneous reactions are among the most frequent adverse reactions to drugs. Most are benign, but a few can be life threatening. Prompt recognition of severe reactions, drug withdrawal, and appropriate therapeutic interventions can minimize toxicity. This chapter focuses on adverse cutaneous reactions to systemic medications; it covers their incidence, patterns, and pathogenesis and provides some practical guidelines on treatment, assessment of causality, and future use of drugs...."
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