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Harrison's Principles of Internal Medicine, 18e | Part 7. Oncology and Hematology > Section 1. Neoplastic Disorders > | Chapter 89. Neoplasms of the Lung Sections: Neoplasms of the Lung: Introduction, Epidemiology, Early Detection and Screening, Clinical Manifestations, Diagnosing Lung Cancer, Staging Lung Cancer, Benign Lung Neoplasms, Further Readings. Topics Discussed: lung cancer; pathophysiology of neoplasia; pathophysiology of pulmonary disease; the genetics of cancer. Excerpt:"Lung cancer is largely a disease of modern man and was considered quite rare before 1900, with fewer than 400 cases described in the medical literature. However, by the mid-twentieth century lung cancer had become epidemic and firmly established as the leading cause of cancer-related death in North America and Europe, killing more than three times as many men as prostate cancer and nearly twice as many women as breast cancer. This fact is particularly distressing since lung cancer is one of the most preventable of all of the common malignancies. Tobacco consumption is the primary cause of lung cancer, a fact firmly established in the mid-twentieth century and codified with the release of the U.S. Surgeon General's 1964 report on the health effects of tobacco smoking. Following the report, cigarette use started to decline in North America and parts of Europe, and with it so did the incidence of lung cancer. To date, the decline in lung cancer is seen most clearly in men; only recently has the decline become apparent among women in the United States. Unfortunately, in many parts of the world, especially in countries with developing economies, cigarette use continues to increase, and along with it, the incidence of lung cancers is also rising. While tobacco smoking remains the primary cause..."
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