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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 1. Neoplastic Disorders > |
Chapter 99. Carcinoma of Unknown Primary
Sections: Carcinoma of Unknown Primary, CUP Biology, Summary, Further Readings.
Topics Discussed: pathophysiology of neoplasia; unknown primary neoplasms.
Excerpt:"Carcinoma of unknown primary (CUP) is a biopsy-proven (mainly epithelial) malignancy for which the anatomic site of origin remains unidentified after an intensive search. CUP is one of the 10 most frequently diagnosed cancers worldwide, accounting for approximately 3–5% of all cancers. Most investigators do not include lymphomas, metastatic melanomas, and metastatic sarcomas that present without a known primary tumor as CUP because these cancers have specific stage- and histology-based treatments that guide management...."
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