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Harrison's Principles of Internal Medicine, 18e
| Part 7. Oncology and Hematology > Section 2. Hematopoietic Disorders > |
Chapter 112. Amyloidosis
Sections: General Principles, AL Amyloidosis, AA Amyloidosis, AF Amyloidosis, A 2M Amyloidosis, Summary, Further Readings.
Topics Discussed: amyloidosis; pathophysiology of disorders of the immune system.
Excerpt:"Amyloidosis is the term for diseases caused by the extracellular deposition of insoluble polymeric protein fibrils in tissues and organs. These diseases are a subset of a growing group of disorders attributed to misfolding of proteins. Among these are Alzheimer's disease and other neurodegenerative diseases, transmissible prion diseases, and genetic diseases caused by mutations that lead to misfolding, aggregation, and protein loss of function, such as certain of the cystic fibrosis mutations. Amyloid fibrils share a common  -pleated sheet structural conformation that confers unique staining properties. The term amyloid was coined by the pathologist Rudolf Virchow around 1854, who thought such deposits were cellulose-like under the microscope...."
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