|
Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 15. Infections Due to RNA Viruses > |
Chapter 193. Rubella (German Measles)
Sections: Rubella (German Measles): Introduction, Further Readings.
Topics Discussed: rubella.
Excerpt:"Rubella was historically viewed as a variant of measles or scarlet fever. Not until the mid-1900s was a separate viral agent for rubella isolated. After an epidemic of rubella in Australia in the early 1940s, the ophthalmologist Norman Gregg noticed the occurrence of congenital cataracts among infants whose mothers had reported rubella infection during early pregnancy, and congenital rubella syndrome (CRS) was first described.Rubella virus is a member of the Togaviridae family and the only member of the genus Rubivirus. This single-stranded RNA enveloped virus measures 50–70 nm in diameter. Its core protein is surrounded by a single-layer lipoprotein envelope with spike-like projections containing two glycoproteins, E1 and E2. There is only one antigenic type of rubella virus, and humans are its only known reservoir.Acquired rubella is characterized by a generalized maculopapular rash that usually lasts for up to 3 days (Fig. 193-1). Up to 50% of rubella virus infections may be subclinical or inapparent. The rash is usually mild and may be difficult to detect in persons with darker skin. In children, rash is usually the first sign of illness. However, in older children and adults, a 1- to 5-day prodrome often precedes..."
The content above is only an excerpt.
For full access, log into an existing user account below,
purchase an annual subscription, or
purchase a short-term subscription to the complete website.
|
|
|
|
Or
|
|
|
|