|
Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 15. Infections Due to RNA Viruses > |
Chapter 196. Infections Caused by Arthropod- and Rodent-Borne Viruses
Sections: Infections Caused by Arthropod- and Rodent-Borne Viruses: Introduction, Fever and Myalgia, Encephalitis, Arthritis and Rash, Hemorrhagic Fevers, Further Readings.
Topics Discussed: arbovirus infections; rodent diseases; zoonoses; zoonotic pathogen; zoonotic viruses.
Excerpt:"Some zoonotic viruses are transmitted in nature without regard to humans and only incidentally infect and produce disease in humans; in addition, a few agents are regularly spread among humans by arthropods. Most of these viruses either are maintained by arthropods or chronically infect rodents. Obviously, the mode of transmission is not a rational basis for taxonomic classification. Indeed, zoonotic viruses from at least seven families act as significant human pathogens (Table 196-1). The virus families differ fundamentally from one another in terms of morphology, replication mechanisms, and genetics. Information on a virus's membership in a family or genus is enlightening with regard to maintenance strategies, sensitivity to antiviral agents, and some aspects of pathogenesis but does not necessarily predict which clinical syndromes (if any) the virus will cause in humans.The Arenaviridae are spherical, 110- to 130-nm particles that bud from the cell's plasma membrane and utilize ambisense RNA genomes with two segments for replication. There are two main phylogenetic branches of Arenaviridae: the Old World viruses, such as Lassa fever and lymphocytic choriomeningitis (LCM) viruses, and the New World viruses, including those causing the South American..."
The content above is only an excerpt.
For full access, log into an existing user account below,
purchase an annual subscription, or
purchase a short-term subscription to the complete website.
|
|
|
|
Or
|
|
|
|