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10/15/2009
Anthrax: Pathophysiology, Recognition, and Clinical Management
by Frederick Southwick, MD
Professor and Chief of Infectious Diseases, University of Florida
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Start the lecture (31 minutes, 48 seconds)
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About this lecture:
Inhalation anthrax is an extremely lethal bacterial disease. Spores can incubate after inhalation for up to 60 days. Once they germinate the bacterium produces two toxins, lethal toxin and edema toxin. Both toxins are capable of inhibiting neutrophil motility and in combination can fully paralyze the host's innate immune response allowing the bacterium to rapidly multiply and overwhelm the host. The clinical manifestations of inhalation anthrax mimic a flu-like syndrome initially, but after 24-48 hours, develop into a fulminant sepsis often accompanied by meningitis. Therapy and prophylaxis regimens are reviewed.
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Disclosure: Dr. Frederick Southwick has no financial interest in or relationship with the manufacturer of any product mentioned in this article or other organization that may have a direct interest in the subject matter of this article. Financial interests include, but are not limited to, employment, consultancies, honoraria, stock options, royalties, grants, research support, and support in preparation of this manuscript.
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