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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11e

Laurence L. Brunton, editor-in-chief
John S. Lazo and Keith L. Parker, Associate Editors

Editors of the online edition:
Laurence L. Brunton, editor-in-chief
Associate Editors: Keith L. Parker, Nelda Murri, Donald K. Blumenthal, and Björn C. Knollmann

In Memoriam
We are sad to report the death of our colleague and friend, Keith Parker. He will always be remembered for his energy, breadth of knowledge, and sparkling ideas. Memorial contributions may be made to endocrinology research at the Keith L. Parker Fund, UT Southwestern Medical Center, P.O. Box 910888, Dallas, Texas 75391-0888.

Preface Preface to the Online Edition Copyright Contributors

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Click on an individual Part title to collapse or expand the Part view.

Part I. General Principles

Chapter 1.	Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Elimination
Chapter 2.	Membrane Transporters and Drug Response
Chapter 3.	Drug Metabolism Latest Update: 12/03/09: St. John’s Wort: A Mini-Review of its Pharmacokinetics and Anti-Depressant Effects
Chapter 4.	Pharmacogenetics
Chapter 5.	The Science of Drug Therapy

Part II. Drugs Acting at Synaptic and Neuroeffector Junctional Sites

Chapter 6.	Neurotransmission: The Autonomic and Somatic Motor Nervous Systems Video: Cholinergic Neuroeffector Junction: Molecular physiology and pharmacology of the cholinergic neuroeffector junction, including the actions of hemicholinium, vesamicol, and botulinum toxin Video: Adrenergic Neuroeffector Junction: Molecular physiology and pharmacology of the adrenergic neuroeffector junction, including the actions of cocaine and reserpine.
Chapter 7.	Muscarinic Receptor Agonists and Antagonists
Chapter 8.	Anticholinesterase Agents
Chapter 9.	Agents Acting at the Neuromuscular Junction and Autonomic Ganglia
Chapter 10.	Adrenergic Agonists and Antagonists
Chapter 11.	5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists

Part III. Drugs Acting on the Central Nervous System

Chapter 12.	Neurotransmission and the Central Nervous System
Chapter 13.	General Anesthetics
Chapter 14.	Local Anesthetics
Chapter 15.	Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium
Chapter 16.	Hypnotics and Sedatives
Chapter 17.	Drug Therapy of Depression and Anxiety Disorders Latest Update: 08/28/09: Clinical Pharmacist's Corner: Fibromyalgia: Still a Rebel Disease without Definitive Treatment
Chapter 18.	Pharmacotherapy of Psychosis and Mania
Chapter 19.	Pharmacotherapy of the Epilepsies Video: GABAergic Synaptic Transmission: This animation illustrates the workings of a GABAergic synapse, including the actions of gamma-amino butyric acid (GABA) and drugs that affect GABAergic neurotransmission.
Chapter 20.	Treatment of Central Nervous System Degenerative Disorders Video: Dopaminergic Neuroeffector Junction: The key features of a typical dopaminergic neuroeffector junction, including the synthesis, storage, and release of dopamine.
Chapter 21.	Opioid Analgesics
Chapter 22.	Ethanol
Chapter 23.	Drug Addiction and Drug Abuse

Part IV. Autacoids: Drug Therapy of Inflammation

Chapter 24.	Histamine, Bradykinin, and Their Antagonists
Chapter 25.	Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor
Chapter 26.	Analgesic-Antipyretic and Antiinflammatory Agents; Pharmacotherapy of Gout
Chapter 27.	Pharmacotherapy of Asthma

Part V. Drugs Affecting Renal and Cardiovascular Function

Chapter 28.	Diuretics
Chapter 29.	Vasopressin and Other Agents Affecting the Renal Conservation of Water
Chapter 30.	Renin and Angiotensin
Chapter 31.	Treatment of Myocardial Ischemia
Chapter 32.	Therapy of Hypertension
Chapter 33.	Pharmacotherapy of Congestive Heart Failure Video: Ventricular Myocyte Electrophysiology: This animation will review the electrophysiology of ventricular myocytes, and the pharmacological effects of drugs used to treat ventricular arrhythmias and heart failure.
Chapter 34.	Antiarrhythmic Drugs Video: Sinus Node Electrophysiology: This animation focuses on the ion channels and transporters that are the primary targets of neurotransmitters of the autonomic nervous system that affect heart rate and drugs used to treat arrhythmias. Video: Atrial Myocyte Electrophysiology: This animation focuses on ion channels and transporters that affect atrial myocyte depolarization, as well as drugs used to treat arrhythmias involving the atria. Video: AV Node Electrophysiology: This animation focuses on the ion channels in the AV node that are the primary targets of neurotransmitters of the autonomic nervous system, and drugs used to treat arrhythmias involving the AV node. Video: Effects of Antiarrhythmic Drugs on the Electrocardiogram: This animation illustrates the effects of various classes of antiarrhythmic drugs on the different regions of the heart and how this results in changes in the electrocardiogram.
Chapter 35.	Drug Therapy for Hypercholesterolemia and Dyslipidemia

Part VI. Drugs Affecting Gastrointestinal Function

Chapter 36.	Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease
Chapter 37.	Treatment of Disorders of Bowel Motility and Water Flux; Antiemetics; Agents Used in Biliary and Pancreatic Disease
Chapter 38.	Pharmacotherapy of Inflammatory Bowel Disease

Part VII. Chemotherapy of Parasitic Infections

Chapter 39.	Chemotherapy of Protozoal Infections: Malaria
Chapter 40.	Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections
Chapter 41.	Chemotherapy of Helminth Infections

Part VIII. Chemotherapy of Microbial Diseases

Chapter 42.	General Principles of Antimicrobial Therapy
Chapter 43.	Sulfonamides, Trimethoprim–Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections
Chapter 44.	Penicillins, Cephalosporins, and Other -Lactam Antibiotics
Chapter 45.	Aminoglycosides
Chapter 46.	Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents
Chapter 47.	*Chemotherapy of Tuberculosis, Mycobacterium avium* Complex Disease, and Leprosy**
Chapter 48.	Antimicrobial Agents: Antifungal Agents
Chapter 49.	Antiviral Agents (Nonretroviral)
Chapter 50.	Antiretroviral Agents and Treatment of HIV Infection

Part IX. Chemotherapy of Neoplastic Diseases

Chapter 51.

Antineoplastic Agents

Part X. Drugs Used for Immunomodulation

Chapter 52.

Immunosuppressants, Tolerogens, and Immunostimulants

Part XI. Drugs Acting on the Blood and the Blood-Forming Organs

Chapter 53.

Hematopoietic Agents: Growth Factors, Minerals, and Vitamins

Chapter 54.

Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs

Latest Update:

09/29/09: Warfarin Pharmacogenetics

Video:

Antiplatelet Drugs: This animation illustrates the various mechanisms by which antiplatelet drugs act to prevent normal and pathological thromboses.

Video:

Parenteral Anticoagulants: This animation reviews the process of coagulation and illustrates the mechanism of action of parenteral anticoagulant drugs.

Video:

Fibrinolytic Drugs: This animation will review the process of normal fibrinolysis and illustrate the mechanism of drugs that are used to remove pathological fibrin clots.

Video:

Oral Anticoagulants: This animation will review the synthesis of vitamin K-dependent coagulation factors and illustrate how warfarin acts to inhibit the final step in the synthesis of these clotting factors.

Part XII. Hormones and Hormone Antagonists

Chapter 55.	Pituitary Hormones and Their Hypothalamic Releasing Hormones
Chapter 56.	Thyroid and Antithyroid Drugs
Chapter 57.	Estrogens and Progestins
Chapter 58.	Androgens
Chapter 59.	Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones
Chapter 60.	Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas
Chapter 61.	Agents Affecting Mineral Ion Homeostasis and Bone Turnover

Part XIII. Dermatology

Chapter 62.

Dermatological Pharmacology

Part XIV. Ophthalmology

Chapter 63.

Ocular Pharmacology

Part XV. Toxicology

Chapter 64.	Principles of Toxicology and Treatment of Poisoning
Chapter 65.	Heavy Metals and Heavy-Metal Antagonists

Appendices

Appendix I.	Principles of Prescription Order Writing and Patient Compliance
Appendix II.	Design and Optimization of Dosage Regimens: Pharmacokinetic Data

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Updates

12/3/2009: St. John’s Wort: A Mini-Review of its Pharmacokinetics and Anti-Depressant Effects Halushka, Perry

9/29/2009: Warfarin Pharmacogenetics Ghimire, Laxmi; Stein, C.

8/28/2009: Clinical Pharmacist's Corner: Fibromyalgia: Still a Rebel Disease without Definitive Treatment Murri, Nelda

View All Updates

Editorial Policy for Updates

The Editors of Goodman & Gilman's welcome your suggestions and submissions for inclusion of updates. If you are a pharmacologist, pharmacist, physician, or medical scientist and you would like the opportunity to contribute an update, please send an email to Editor-in-Chief Laurence Brunton at gg_updates@mhedu.com.

Animations

Flash Player 8 or higher required (Get Flash)

		Oral Anticoagulants

		Fibrinolytic Drugs

		Parenteral Anticoagulants

		Antiplatelet Drugs

		Effects of Antiarrhythmic Drugs on the Electrocardiogram

		Ventricular Myocyte Electrophysiology

		AV Node Electrophysiology

		Atrial Myocyte Electrophysiology

		Sinus Node Electrophysiology

		GABAergic Synaptic Transmission

		Dopaminergic Neuroeffector Junction

		Adrenergic Neuroeffector Junction

		Cholinergic Neuroeffector Junction