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Harrison's Online

Featuring the complete contents of Harrison's Principles of
Internal Medicine, 18e

Dan L. Longo, Anthony S. Fauci, Dennis L. Kasper, Stephen L. Hauser, J. Larry Jameson, Joseph Loscalzo, Eds.

Preface     Copyright     Contributors

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 Part 1. Introduction to Clinical Medicine
 Chapter 1The Practice of Medicine
 Chapter 2Global Issues in Medicine
 Chapter 3Decision-Making in Clinical Medicine
Lecture Notes:
 Chapter 4Screening and Prevention of Disease
Lecture Notes:
 Chapter 5Principles of Clinical Pharmacology
Lecture Notes:
 Chapter 6Women's Health
 Chapter 7Medical Disorders During Pregnancy
 Chapter 8Medical Evaluation of the Surgical Patient
 Chapter 9Palliative and End-of-Life Care
 Chapter 10The Safety and Quality of Health Care
Lecture Notes:
Chapter e1Primary Care in Low- and Middle-Income Countries
Chapter e2Complementary, Alternative, and Integrative Medicine
Lecture Notes:
Chapter e3The Economics of Medical Care
Chapter e4Racial and Ethnic Disparities in Health Care
Chapter e5Ethical Issues in Clinical Medicine
Chapter e6Neoplasia During Pregnancy
 Part 2. Cardinal Manifestations and Presentation of Diseases
 Section 1. Pain
 Chapter 11Pain: Pathophysiology and Management
Latest Update:

Lecture Notes:
 Chapter 12Chest Discomfort
Lecture Notes:
 Chapter 13Abdominal Pain
Lecture Notes:
 Chapter 14Headache
Latest Update:

Lecture Notes:
 Chapter 15Back and Neck Pain
Lecture Notes:

 Section 2. Alterations in Body Temperature
 Chapter 16Fever and Hyperthermia
Lecture Notes:
 Chapter 17Fever and Rash
Lecture Notes:
Chapter e7Atlas of Rashes Associated With Fever
Lecture Notes:
 Chapter 18Fever of Unknown Origin
Lecture Notes:
 Chapter 19Hypothermia and Frostbite
Lecture Notes:

 Section 3. Nervous System Dysfunction
 Chapter 20Syncope
Latest Update:

Lecture Notes:
 Chapter 21Dizziness and Vertigo
Lecture Notes:
 Chapter 22Weakness and Paralysis
Lecture Notes:
 Chapter 23Numbness, Tingling, and Sensory Loss
Lecture Notes:
 Chapter 24Gait and Balance Disorders
Lecture Notes:
Chapter e8Video Library of Gait Disorders
Lecture Notes:
 Chapter 25Confusion and Delirium
Latest Update:

Lecture Notes:
 Chapter 26Aphasia, Memory Loss, and Other Focal Cerebral Disorders
Latest Update:

Lecture Notes:
Chapter e9Memory Loss
Lecture Notes:
Chapter e10Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
Lecture Notes:
 Chapter 27Sleep Disorders
Latest Update:

Lecture Notes:

 Section 4. Disorders of Eyes, Ears, Nose, and Throat
 Chapter 28Disorders of the Eye
Latest Update:

Lecture Notes:
Chapter e11Video Library of Neuro-Ophthalmology
Lecture Notes:
 Chapter 29Disorders of Smell and Taste
Lecture Notes:
 Chapter 30Disorders of Hearing
Lecture Notes:
 Chapter 31Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections
Lecture Notes:
 Chapter 32Oral Manifestations of Disease
Lecture Notes:
Chapter e12Atlas of Oral Manifestations of Disease
Lecture Notes:

 Section 5. Alterations in Circulatory and Respiratory Functions
 Chapter 33Dyspnea
Lecture Notes:
 Chapter 34Cough and Hemoptysis
Lecture Notes:
 Chapter 35Hypoxia and Cyanosis
Lecture Notes:
 Chapter 36Edema
Lecture Notes:
Chapter e13Approach to the Patient with a Heart Murmur
Lecture Notes:
 Chapter 37Palpitations
Lecture Notes:

 Section 6. Alterations in Gastrointestinal Function
 Chapter 38Dysphagia
Lecture Notes:
 Chapter 39Nausea, Vomiting, and Indigestion
Lecture Notes:
 Chapter 40Diarrhea and Constipation
Latest Update:

Lecture Notes:
 Chapter 41Gastrointestinal Bleeding
Latest Update:

Lecture Notes:
 Chapter 42Jaundice
Lecture Notes:
 Chapter 43Abdominal Swelling and Ascites
Lecture Notes:

 Section 7. Alterations in Renal and Urinary Tract Function
 Chapter 44Azotemia and Urinary Abnormalities
Lecture Notes:
Chapter e14Atlas of Urinary Sediments and Renal Biopsies
Lecture Notes:
 Chapter 45Fluid and Electrolyte Disturbances
Latest Update:

Lecture Notes:
Chapter e15Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
Lecture Notes:
 Chapter 46Hypercalcemia and Hypocalcemia
Lecture Notes:
 Chapter 47Acidosis and Alkalosis
Lecture Notes:

 Section 8. Alterations in Sexual Function and Reproduction
 Chapter 48Sexual Dysfunction
Lecture Notes:
 Chapter 49Hirsutism and Virilization
Lecture Notes:
 Chapter 50Menstrual Disorders and Pelvic Pain
Lecture Notes:

 Section 9. Alterations in the Skin
 Chapter 51Approach to the Patient with a Skin Disorder
Lecture Notes:
 Chapter 52Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Lecture Notes:
 Chapter 53Skin Manifestations of Internal Disease
Lecture Notes:
 Chapter 54Immunologically Mediated Skin Diseases
Lecture Notes:
 Chapter 55Cutaneous Drug Reactions
Lecture Notes:
 Chapter 56Photosensitivity and Other Reactions to Light
Lecture Notes:
Chapter e16Atlas of Skin Manifestations of Internal Disease
Lecture Notes:

 Section 10. Hematologic Alterations
 Chapter 57Anemia and Polycythemia
Lecture Notes:
 Chapter 58Bleeding and Thrombosis
Lecture Notes:
 Chapter 59Enlargement of Lymph Nodes and Spleen
Lecture Notes:
 Chapter 60Disorders of Granulocytes and Monocytes
Lecture Notes:
Chapter e17Atlas of Hematology and Analysis of Peripheral Blood Smears
Lecture Notes:
 Part 3. Genes, the Environment, and Disease
 Chapter 61Principles of Human Genetics
Latest Update:

Lecture Notes:
 Chapter 62Chromosome Disorders
 Chapter 63The Practice of Genetics in Clinical Medicine
Lecture Notes:
Chapter e18Mitochondrial DNA and Heritable Traits and Diseases
 Chapter 64The Human Microbiome
Chapter e19Systems Biology in Health and Disease
 Part 4. Regenerative Medicine
 Chapter 65Stem Cell Biology
Lecture Notes:
 Chapter 66Hematopoietic Stem Cells
Lecture Notes:
 Chapter 67Applications of Stem Cell Biology in Clinical Medicine
 Chapter 68Gene Therapy in Clinical Medicine
 Chapter 69Tissue Engineering
 Part 5. Aging
 Chapter 70World Demography of Aging
 Chapter 71The Biology of Aging
 Chapter 72Clinical Problems of Aging
 Part 6. Nutrition
 Chapter 73Nutrient Requirements and Dietary Assessment
 Chapter 74Vitamin and Trace Mineral Deficiency and Excess
Lecture Notes:
 Chapter 75Malnutrition and Nutritional Assessment
Lecture Notes:
 Chapter 76Enteral and Parenteral Nutrition Therapy
 Chapter 77Biology of Obesity
 Chapter 78Evaluation and Management of Obesity
Lecture Notes:
 Chapter 79Eating Disorders
 Chapter 80Involuntary Weight Loss
Lecture Notes:
 Part 7. Oncology and Hematology
 Section 1. Neoplastic Disorders
 Chapter 81Approach to the Patient with Cancer
Latest Update:

Lecture Notes:
 Chapter 82Prevention and Early Detection of Cancer
Latest Update:
 Chapter 83Cancer Genetics
Lecture Notes:
 Chapter 84Cancer Cell Biology and Angiogenesis
Lecture Notes:
 Chapter 85Principles of Cancer Treatment
Latest Update:

Lecture Notes:
 Chapter 86Infections in Patients with Cancer
Lecture Notes:
 Chapter 87Cancer of the Skin
Lecture Notes:
 Chapter 88Head and Neck Cancer
 Chapter 89Neoplasms of the Lung
Latest Update:

Lecture Notes:
 Chapter 90Breast Cancer
Latest Update:

Lecture Notes:
 Chapter 91Gastrointestinal Tract Cancer
Latest Update:

Lecture Notes:
 Chapter 92Tumors of the Liver and Biliary Tree
 Chapter 93Pancreatic Cancer
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 Chapter 94Bladder and Renal Cell Carcinomas
 Chapter 95Benign and Malignant Diseases of the Prostate
 Chapter 96Testicular Cancer
 Chapter 97Gynecologic Malignancies
 Chapter 98Soft Tissue and Bone Sarcomas and Bone Metastases
 Chapter 99Carcinoma of Unknown Primary
 Chapter 100Paraneoplastic Syndromes: Endocrinologic/Hematologic
 Chapter 101Paraneoplastic Neurologic Syndromes
Chapter e20Thymoma
 Chapter 102Late Consequences of Cancer and Its Treatment

 Section 2. Hematopoietic Disorders
 Chapter 103Iron Deficiency and Other Hypoproliferative Anemias
Lecture Notes:
 Chapter 104Disorders of Hemoglobin
Lecture Notes:
 Chapter 105Megaloblastic Anemias
Lecture Notes:
 Chapter 106Hemolytic Anemias and Anemia Due to Acute Blood Loss
Lecture Notes:
 Chapter 107Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
Lecture Notes:
 Chapter 108Polycythemia Vera and Other Myeloproliferative Diseases
Lecture Notes:
 Chapter 109Acute and Chronic Myeloid Leukemia
Latest Update:

Lecture Notes:
 Chapter 110Malignancies of Lymphoid Cells
Lecture Notes:
Chapter e21Less Common Hematologic Malignancies
 Chapter 111Plasma Cell Disorders
 Chapter 112Amyloidosis
 Chapter 113Transfusion Biology and Therapy
 Chapter 114Hematopoietic Cell Transplantation

 Section 3. Disorders of Hemostasis
 Chapter 115Disorders of Platelets and Vessel Wall
Lecture Notes:
 Chapter 116Coagulation Disorders
Lecture Notes:
 Chapter 117Arterial and Venous Thrombosis
 Chapter 118Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Lecture Notes:
 Part 8. Infectious Diseases
 Section 1. Basic Considerations in Infectious Diseases
 Chapter 119Introduction to Infectious Diseases: Host–Pathogen Interactions
Lecture Notes:
 Chapter 120Molecular Mechanisms of Microbial Pathogenesis
Lecture Notes:
 Chapter 121Approach to the Acutely Ill Infected Febrile Patient
Lecture Notes:
 Chapter 122Immunization Principles and Vaccine Use
Lecture Notes:
 Chapter 123Health Recommendations for International Travel
Lecture Notes:
Chapter e22Laboratory Diagnosis of Infectious Diseases
Lecture Notes:

 Section 2. Clinical Syndromes: Community-Acquired Infections
 Chapter 124Infective Endocarditis
Latest Update:

Lecture Notes:
 Chapter 125Infections of the Skin, Muscles, and Soft Tissues
Lecture Notes:
 Chapter 126Osteomyelitis
Lecture Notes:
 Chapter 127Intraabdominal Infections and Abscesses
Lecture Notes:
 Chapter 128Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Lecture Notes:
 Chapter 129Clostridium Difficile Infection, Including Pseudomembranous Colitis
Latest Update:

Lecture Notes:
 Chapter 130Sexually Transmitted Infections: Overview and Clinical Approach
Lecture Notes:
Chapter e23Infectious Complications of Burns
Lecture Notes:
Chapter e24Infectious Complications of Bites
Lecture Notes:

 Section 3. Clinical Syndromes: Health Care–Associated Infections
 Chapter 131Health Care–Associated Infections
Latest Update:
 Chapter 132Infections in Transplant Recipients

 Section 4. Approach to Therapy for Bacterial Diseases
 Chapter 133Treatment and Prophylaxis of Bacterial Infections
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 Section 5. Diseases Caused by Gram-Positive Bacteria
 Chapter 134Pneumococcal Infections
 Chapter 135Staphylococcal Infections
 Chapter 136Streptococcal Infections
 Chapter 137Enterococcal Infections
 Chapter 138Diphtheria and Other Infections Caused by Corynebacteria and Related Species
 Chapter 139Listeria Monocytogenes Infections
 Chapter 140Tetanus
 Chapter 141Botulism
 Chapter 142Gas Gangrene and Other Clostridial Infections

 Section 6. Diseases Caused by Gram-Negative Bacteria
 Chapter 143Meningococcal Infections
Latest Update:
 Chapter 144Gonococcal Infections
 Chapter 145Haemophilus and Moraxella Infections
 Chapter 146Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
 Chapter 147Legionella Infections
 Chapter 148Pertussis and Other Bordetella Infections
 Chapter 149Diseases Caused by Gram-Negative Enteric Bacilli
 Chapter 150Acinetobacter Infections
 Chapter 151Helicobacter pylori Infections
 Chapter 152Infections Due to Pseudomonas Species and Related Organisms
 Chapter 153Salmonellosis
 Chapter 154Shigellosis
 Chapter 155Infections Due to Campylobacter and Related Organisms
 Chapter 156Cholera and Other Vibrioses
 Chapter 157Brucellosis
 Chapter 158Tularemia
 Chapter 159Plague and Other Yersinia Infections
 Chapter 160Bartonella Infections, Including Cat-Scratch Disease
 Chapter 161Donovanosis

 Section 7. Miscellaneous Bacterial Infections
 Chapter 162Nocardiosis
 Chapter 163Actinomycosis
 Chapter 164Infections Due to Mixed Anaerobic Organisms

 Section 8. Mycobacterial Diseases
 Chapter 165Tuberculosis
Latest Update:

Lecture Notes:
 Chapter 166Leprosy
 Chapter 167Nontuberculous Mycobacterial Infections
 Chapter 168Antimycobacterial Agents

 Section 9. Spirochetal Diseases
 Chapter 169Syphilis
 Chapter 170Endemic Treponematoses
 Chapter 171Leptospirosis
 Chapter 172Relapsing Fever
 Chapter 173Lyme Borreliosis
Latest Update:

 Section 10. Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
 Chapter 174Rickettsial Diseases
 Chapter 175Infections Due to Mycoplasmas
 Chapter 176Chlamydial Infections

 Section 11. Viral Diseases: General Considerations
 Chapter 177Medical Virology
Lecture Notes:
 Chapter 178Antiviral Chemotherapy, Excluding Antiretroviral Drugs

 Section 12. Infections Due to DNA Viruses
 Chapter 179Herpes Simplex Virus Infections
Latest Update:
 Chapter 180Varicella-Zoster Virus Infections
 Chapter 181Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Lecture Notes:
 Chapter 182Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
 Chapter 183Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections
 Chapter 184Parvovirus Infections
 Chapter 185Human Papillomavirus Infections

 Section 13. Infections Due to DNA and RNA Respiratory Viruses
 Chapter 186Common Viral Respiratory Infections
 Chapter 187Influenza
Lecture Notes:

 Section 14. Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
 Chapter 188The Human Retroviruses
Lecture Notes:
 Chapter 189Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Lecture Notes:

 Section 15. Infections Due to RNA Viruses
 Chapter 190Viral Gastroenteritis
 Chapter 191Enteroviruses and Reoviruses
 Chapter 192Measles (Rubeola)
 Chapter 193Rubella (German Measles)
 Chapter 194Mumps
 Chapter 195Rabies and Other Rhabdovirus Infections
 Chapter 196Infections Caused by Arthropod- and Rodent-Borne Viruses
 Chapter 197Ebola and Marburg Viruses

 Section 16. Fungal Infections
 Chapter 198Diagnosis and Treatment of Fungal Infections
 Chapter 199Histoplasmosis
 Chapter 200Coccidioidomycosis
 Chapter 201Blastomycosis
 Chapter 202Cryptococcosis
 Chapter 203Candidiasis
 Chapter 204Aspergillosis
 Chapter 205Mucormycosis
 Chapter 206Superficial Mycoses and Less Common Systemic Mycoses
 Chapter 207Pneumocystis Infections

 Section 17. Protozoal and Helminthic Infections: General Considerations
Chapter e25Laboratory Diagnosis of Parasitic Infections
 Chapter 208Agents Used to Treat Parasitic Infections
Chapter e26Pharmacology of Agents Used to Treat Parasitic Infections

 Section 18. Protozoal Infections
 Chapter 209Amebiasis and Infection With Free-Living Amebas
 Chapter 210Malaria
Lecture Notes:
 Chapter 211Babesiosis
Chapter e27Atlas of Blood Smears of Malaria and Babesiosis
 Chapter 212Leishmaniasis
 Chapter 213Chagas' Disease and Trypanosomiasis
 Chapter 214Toxoplasma Infections
 Chapter 215Protozoal Intestinal Infections and Trichomoniasis

 Section 19. Helminthic Infections
 Chapter 216Trichinellosis and Other Tissue Nematode Infections
 Chapter 217Intestinal Nematode Infections
 Chapter 218Filarial and Related Infections
 Chapter 219Schistosomiasis and Other Trematode Infections
 Chapter 220Cestode Infections
 Part 9. Terrorism and Clinical Medicine
 Chapter 221Microbial Bioterrorism
 Chapter 222Chemical Terrorism
 Chapter 223Radiation Terrorism
 Part 10. Disorders of the Cardiovascular System
 Section 1. Introduction to Cardiovascular Disorders
 Chapter 224Basic Biology of the Cardiovascular System
Lecture Notes:
 Chapter 225Epidemiology of Cardiovascular Disease
Latest Update:
 Chapter 226Approach to the Patient with Possible Cardiovascular Disease

 Section 2. Diagnosis of Cardiovascular Disorders
 Chapter 227Physical Examination of the Cardiovascular System
Lecture Notes:
 Chapter 228Electrocardiography
Latest Update:
Chapter e28Atlas of Electrocardiography
 Chapter 229Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
Latest Update:
Chapter e29Atlas of Noninvasive Cardiac Imaging
 Chapter 230Diagnostic Cardiac Catheterization and Coronary Angiography

 Section 3. Disorders of Rhythm
 Chapter 231Principles of Electrophysiology
 Chapter 232The Bradyarrhythmias
 Chapter 233The Tachyarrhythmias
Latest Update:
Chapter e30Atlas of Cardiac Arrhythmias

 Section 4. Disorders of the Heart
 Chapter 234Heart Failure and Cor Pulmonale
Latest Update:
 Chapter 235Cardiac Transplantation and Prolonged Assisted Circulation
 Chapter 236Congenital Heart Disease in the Adult
 Chapter 237Valvular Heart Disease
Latest Update:
 Chapter 238Cardiomyopathy and Myocarditis
Latest Update:
 Chapter 239Pericardial Disease
 Chapter 240Tumors and Trauma of the Heart
Chapter e31Cardiac Manifestations of Systemic Disease

 Section 5. Vascular Disease
 Chapter 241The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Chapter e32Atlas of Atherosclerosis
 Chapter 242The Metabolic Syndrome
Latest Update:
 Chapter 243Ischemic Heart Disease
Latest Update:
 Chapter 244Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction
Latest Update:
 Chapter 245ST-Segment Elevation Myocardial Infarction
 Chapter 246Percutaneous Coronary Interventions and Other Interventional Procedures
Latest Update:
Chapter e33Atlas of Percutaneous Revascularization
 Chapter 247Hypertensive Vascular Disease
Latest Update:

Lecture Notes:
 Chapter 248Diseases of the Aorta
Latest Update:
 Chapter 249Vascular Diseases of the Extremities
Latest Update:
 Chapter 250Pulmonary Hypertension
 Part 11. Disorders of the Respiratory System
 Section 1. Diagnosis of Respiratory Disorders
 Chapter 251Approach to the Patient with Disease of the Respiratory System
 Chapter 252Disturbances of Respiratory Function
Lecture Notes:
 Chapter 253Diagnostic Procedures in Respiratory Disease
Chapter e34Atlas of Chest Imaging

 Section 2. Diseases of the Respiratory System
 Chapter 254Asthma
Latest Update:
 Chapter 255Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
 Chapter 256Occupational and Environmental Lung Disease
Latest Update:
 Chapter 257Pneumonia
Lecture Notes:
 Chapter 258Bronchiectasis and Lung Abscess
Latest Update:
 Chapter 259Cystic Fibrosis
 Chapter 260Chronic Obstructive Pulmonary Disease
Latest Update:
 Chapter 261Interstitial Lung Diseases
Latest Update:
 Chapter 262Deep Venous Thrombosis and Pulmonary Thromboembolism
Lecture Notes:
 Chapter 263Disorders of the Pleura and Mediastinum
 Chapter 264Disorders of Ventilation
 Chapter 265Sleep Apnea
Latest Update:
 Chapter 266Lung Transplantation
 Part 12. Critical Care Medicine
 Section 1. Respiratory Critical Care
 Chapter 267Approach to the Patient with Critical Illness
 Chapter 268Acute Respiratory Distress Syndrome
Lecture Notes:
 Chapter 269Mechanical Ventilatory Support

 Section 2. Shock and Cardiac Arrest
 Chapter 270Approach to the Patient with Shock
Lecture Notes:
 Chapter 271Severe Sepsis and Septic Shock
Lecture Notes:
 Chapter 272Cardiogenic Shock and Pulmonary Edema
Lecture Notes:
 Chapter 273Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Lecture Notes:

 Section 3. Neurologic Critical Care
 Chapter 274Coma
Latest Update:

Lecture Notes:
 Chapter 275Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy, and Subarachnoid Hemorrhage
Lecture Notes:

 Section 4. Oncologic Emergencies
 Chapter 276Oncologic Emergencies
 Part 13. Disorders of the Kidney and Urinary Tract
 Chapter 277Cellular and Molecular Biology of the Kidney
Lecture Notes:
 Chapter 278Adaption of the Kidney to Renal Injury
Lecture Notes:
 Chapter 279Acute Kidney Injury
Lecture Notes:
 Chapter 280Chronic Kidney Disease
Lecture Notes:
 Chapter 281Dialysis in the Treatment of Renal Failure
Lecture Notes:
 Chapter 282Transplantation in the Treatment of Renal Failure
Lecture Notes:
 Chapter 283Glomerular Diseases
Latest Update:

Lecture Notes:
 Chapter 284Polycystic Kidney Disease and Other Inherited Tubular Disorders
Lecture Notes:
 Chapter 285Tubulointerstitial Diseases of the Kidney
Lecture Notes:
 Chapter 286Vascular Injury to the Kidney
Lecture Notes:
 Chapter 287Nephrolithiasis
Lecture Notes:
 Chapter 288Urinary Tract Infections, Pyelonephritis, and Prostatitis
Lecture Notes:
Chapter e35Interstitial Cystitis/Painful Bladder Syndrome
Lecture Notes:
 Chapter 289Urinary Tract Obstruction
Lecture Notes:
 Part 14. Disorders of the Gastrointestinal System
 Section 1. Disorders of the Alimentary Tract
 Chapter 290Approach to the Patient with Gastrointestinal Disease
Latest Update:

Lecture Notes:
 Chapter 291Gastrointestinal Endoscopy
Chapter e36Video Atlas of Gastrointestinal Endoscopy
 Chapter 292Diseases of the Esophagus
 Chapter 293Peptic Ulcer Disease and Related Disorders
 Chapter 294Disorders of Absorption
Latest Update:
Chapter e37The Schilling Test
 Chapter 295Inflammatory Bowel Disease
Latest Update:

Lecture Notes:
 Chapter 296Irritable Bowel Syndrome
Latest Update:
 Chapter 297Diverticular Disease and Common Anorectal Disorders
Latest Update:
 Chapter 298Mesenteric Vascular Insufficiency
 Chapter 299Acute Intestinal Obstruction
 Chapter 300Acute Appendicitis and Peritonitis

 Section 2. Liver and Biliary Tract Disease
 Chapter 301Approach to the Patient with Liver Disease
Lecture Notes:
 Chapter 302Evaluation of Liver Function
Lecture Notes:
 Chapter 303The Hyperbilirubinemias
 Chapter 304Acute Viral Hepatitis
Latest Update:
 Chapter 305Toxic and Drug-Induced Hepatitis
Latest Update:
 Chapter 306Chronic Hepatitis
Latest Update:
 Chapter 307Alcoholic Liver Disease
Latest Update:
 Chapter 308Cirrhosis and Its Complications
Latest Update:
Chapter e38Atlas of Liver Biopsies
 Chapter 309Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
Latest Update:
 Chapter 310Liver Transplantation
Latest Update:
 Chapter 311Diseases of the Gallbladder and Bile Ducts

 Section 3. Disorders of the Pancreas
 Chapter 312Approach to the Patient with Pancreatic Disease
Lecture Notes:
 Chapter 313Acute and Chronic Pancreatitis
Latest Update:
 Part 15. Disorders of the Joints and Adjacent Tissues
 Section 1. The Immune System in Health and Disease
 Chapter 314Introduction to the Immune System
Lecture Notes:
 Chapter 315The Major Histocompatibility Complex
Lecture Notes:
 Chapter 316Primary Immune Deficiency Diseases
Chapter e39Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases

 Section 2. Disorders of Immune-Mediated Injury
 Chapter 317Allergies, Anaphylaxis, and Systemic Mastocytosis
Lecture Notes:
 Chapter 318Autoimmunity and Autoimmune Diseases
 Chapter 319Systemic Lupus Erythematosus
 Chapter 320Antiphospholipid Antibody Syndrome
 Chapter 321Rheumatoid Arthritis
Lecture Notes:
 Chapter 322Acute Rheumatic Fever
 Chapter 323Systemic Sclerosis (Scleroderma) and Related Disorders
 Chapter 324Sjögren's Syndrome
 Chapter 325The Spondyloarthritides
 Chapter 326The Vasculitis Syndromes
Chapter e40Atlas of the Vasculitic Syndromes
 Chapter 327Behçet's Syndrome
 Chapter 328Relapsing Polychondritis
 Chapter 329Sarcoidosis
 Chapter 330Familial Mediterranean Fever and Other Hereditary Recurrent Fevers

 Section 3. Disorders of the Joints and Adjacent Tissues
 Chapter 331Approach to Articular and Musculoskeletal Disorders
Lecture Notes:
 Chapter 332Osteoarthritis
Lecture Notes:
 Chapter 333Gout and Other Crystal-Associated Arthropathies
 Chapter 334Infectious Arthritis
 Chapter 335Fibromyalgia
 Chapter 336Arthritis Associated with Systemic Disease, and Other Arthritides
 Chapter 337Periarticular Disorders of the Extremities
 Part 16. Endocrinology and Metabolism
 Section 1. Endocrinology
 Chapter 338Principles of Endocrinology
Lecture Notes:
 Chapter 339Disorders of the Anterior Pituitary and Hypothalamus
 Chapter 340Disorders of the Neurohypophysis
 Chapter 341Disorders of the Thyroid Gland
Lecture Notes:
 Chapter 342Disorders of the Adrenal Cortex
Lecture Notes:
 Chapter 343Pheochromocytoma
 Chapter 344Diabetes Mellitus
Lecture Notes:
 Chapter 345Hypoglycemia
Lecture Notes:
 Chapter 346Disorders of the Testes and Male Reproductive System
 Chapter 347The Female Reproductive System, Infertility, and Contraception
 Chapter 348The Menopause Transition and Postmenopausal Hormone Therapy
 Chapter 349Disorders of Sex Development
 Chapter 350Endocrine Tumors of the Gastrointestinal Tract and Pancreas
Latest Update:
 Chapter 351Disorders Affecting Multiple Endocrine Systems

 Section 2. Disorders of Bone and Mineral Metabolism
 Chapter 352Bone and Mineral Metabolism in Health and Disease
 Chapter 353Disorders of the Parathyroid Gland and Calcium Homeostasis
 Chapter 354Osteoporosis
Lecture Notes:
 Chapter 355Paget's Disease and Other Dysplasias of Bone

 Section 3. Disorders of Intermediary Metabolism
 Chapter 356Disorders of Lipoprotein Metabolism
 Chapter 357Hemochromatosis
Lecture Notes:
 Chapter 358The Porphyrias
Lecture Notes:
 Chapter 359Disorders of Purine and Pyrimidine Metabolism
 Chapter 360Wilson's Disease
 Chapter 361Lysosomal Storage Diseases
 Chapter 362Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
 Chapter 363Heritable Disorders of Connective Tissue
 Chapter 364Inherited Disorders of Amino Acid Metabolism in Adults
 Chapter 365Inherited Defects of Membrane Transport
Chapter e41Atlas of Clinical Manifestations of Metabolic Diseases
 Part 17. Neurologic Disorders
 Section 1. Diagnosis of Neurologic Disorders
 Chapter 366Biology of Neurologic Diseases
Lecture Notes:
 Chapter 367Approach to the Patient with Neurologic Disease
Lecture Notes:
Chapter e42The Neurologic Screening Exam
Chapter e43Video Atlas of the Detailed Neurologic Examination
 Chapter 368Neuroimaging in Neurologic Disorders
Chapter e44Atlas of Neuroimaging
Chapter e45Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG
Chapter e46Technique of Lumbar Puncture

 Section 2. Diseases of the Central Nervous System
 Chapter 369Seizures and Epilepsy
Latest Update:
 Chapter 370Cerebrovascular Diseases
Latest Update:

Lecture Notes:
 Chapter 371Dementia
Latest Update:

Lecture Notes:
 Chapter 372Parkinson's Disease and Other Movement Disorders
Latest Update:

Lecture Notes:
 Chapter 373Ataxic Disorders
 Chapter 374Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
 Chapter 375Disorders of the Autonomic Nervous System
 Chapter 376Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders
 Chapter 377Diseases of the Spinal Cord
 Chapter 378Concussion and Other Head Injuries
Latest Update:

Lecture Notes:
 Chapter 379Primary and Metastatic Tumors of the Nervous System
 Chapter 380Multiple Sclerosis and Other Demyelinating Diseases
Latest Update:

Lecture Notes:
 Chapter 381Meningitis, Encephalitis, Brain Abscess, and Empyema
Latest Update:

Lecture Notes:
 Chapter 382Chronic and Recurrent Meningitis
 Chapter 383Prion Diseases
Latest Update:

 Section 3. Nerve and Muscle Disorders
 Chapter 384Peripheral Neuropathy
Latest Update:

Lecture Notes:
 Chapter 385Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
Latest Update:
 Chapter 386Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
 Chapter 387Muscular Dystrophies and Other Muscle Diseases
Latest Update:
 Chapter 388Polymyositis, Dermatomyositis, and Inclusion Body Myositis
Chapter e47Special Issues in Inpatient Neurologic Consultation

 Section 4. Chronic Fatigue Syndrome
 Chapter 389Chronic Fatigue Syndrome

 Section 5. Psychiatric Disorders
 Chapter 390Biology of Psychiatric Disorders
Lecture Notes:
 Chapter 391Mental Disorders
Latest Update:

 Section 6. Alcoholism and Drug Dependency
 Chapter 392Alcohol and Alcoholism
 Chapter 393Opioid Drug Abuse and Dependence
 Chapter 394Cocaine and Other Commonly Abused Drugs
 Chapter 395Nicotine Addiction
Latest Update:
Chapter e48Neuropsychiatric Illnesses in War Veterans
 Part 18. Poisoning, Drug Overdose, and Envenomation
Chapter e49Heavy Metal Poisoning
Chapter e50Poisoning and Drug Overdosage
 Chapter 396Disorders Caused by Venomous Snakebites and Marine Animal Exposures
 Chapter 397Ectoparasite Infestations and Arthropod Bites and Stings
 Part 19. High-Altitude and Decompression Sickness
Chapter e51Altitude Illness
Chapter e52Hyperbaric and Diving Medicine
  


Appendix: Laboratory Values of Clinical Importance






Chapter e53


The Clinical Laboratory in Modern Health Care






Clinical Procedure Tutorials: Introduction
Chapter e54Clinical Procedure Tutorial: Central Venous Catheter Placement [video]
Chapter e55Clinical Procedure Tutorial: Thoracentesis [video]
Chapter e56Clinical Procedure Tutorial: Abdominal Paracentesis [video]
Chapter e57Clinical Procedure Tutorial: Endotracheal Intubation [video]
Chapter e58Clinical Procedural Tutorial: Phlebotomy [video]
Chapter e59Clinical Procedural Tutorial: Insertion of Female Urethral Catheter [video]
Chapter e60Clinical Procedural Tutorial: Insertion of Male Urethral Catheter [video]
Chapter e61Clinical Procedural Tutorial: Fine Needle Aspiration of Breast Cyst [video]
Chapter e62Clinical Procedural Tutorial: IV Insertion [video]



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